This report summarizes a 2021 workshop organized by the National Academies of Sciences, Engineering, and Medicine’s Roundtable on Health Literacy. The workshop examined the experiences that individuals with low health literacy have with using virtual or telehealth services; best practices for ensuring that individuals with low health literacy are able to obtain, process, understand, and act upon health information and services provided virtually or through telehealth; and health system and provider strategies for ensuring the delivery of health literate virtual health services that benefit patients and practitioners alike.