Higher educational attainment is strongly associated with better health, but we know far less about how other social determinants, such as literacy and continuing participation in formal and non-formal education, shape health outcomes. This paper uses PIAAC data for U.S. adults to analyze the relationship between respondents’ self-reported health and (a) literacy, numeracy, and technological problem-solving skills, and (b) post-initial learning, and to determine whether those relationships vary by race/ethnicity and formal educational attainment. Post-initial learning includes the pursuit of formal and non-formal education and training beyond the respondent’s highest level of completed schooling.