This study examines how the COVID-19 infodemic created multilevel barriers to vaccine decision-making in a high social vulnerability community. Using the Social Ecology of Health Beliefs and Misinformation Framework, we identified community-recommended solutions concentrated at the interpersonal and community levels. Findings highlight the critical need for health literacy interventions delivered by culturally concordant, hyperlocal trusted messengers and partnerships with faith-based organizations. Practical tools include health literacy and cultural humility training for community health workers and community-based organizations. These strategies offer actionable, community-driven solutions to combat health misinformation and strengthen information ecosystem resilience for future public health crises.